Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g., JJC8-091).Interestingly, the only distinction between sulfoxide and sulfide substitution is the pre
The increasing population in an area often triggers heightened development, leading to diminished land availability and subsequent land conversion.This transformation, predominantly observed in agricultural and plantation lands, is driven After Sun Care by the need for residential areas.However, continuous land use changes contribute to erosion, a
COVID-19 vaccination rates have been low among adults in Kenya (36.7% as of late March 2023) with vaccine hesitancy posing a threat to the COVID-19 vaccination program.This study sought to examine facilitators and barriers to COVID-19 vaccinations in Kenya.We conducted a qualitative cross-sectional study in two purposively selected counties in Keny
Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the epigenetic modifications of DNA.Initially Eye described as catalyzing the oxidation of methyl cytosine (5mC) to hydroxymethyl cytosine (5hmC), it is now clear that these enzymes can